Side effects of filler dissolution injections you may not know about

19/12/25
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Filler dissolution injections are a popular cosmetic procedure chosen by many to correct previously injected fillers, addressing errors or dissatisfaction with the results. However, not everyone understands the side effects of filler dissolution injections, ranging from common mild reactions to rare conditions that can affect the skin. Let’s explore the possible side effects of filler dissolution injections in this article from Hbio Clinic!

When is filler dissolution necessary?

You should consider filler dissolution injections in the following cases:
  • Incorrect or unbalanced filler injection: If the filler is injected incorrectly or deviates from the desired shape (e.g., uneven lips, a bumpy nose, or unbalanced cheekbones), filler dissolution injections help adjust it to a natural shape.
  • Excessive filler or hardening of the filler: When the amount of filler injected is excessive or the filler is too hard, causing swelling, unevenness, or an unattractive appearance, filler dissolution injections will help dissolve the excess filler and adjust the results.
  • Post-injection complications: Reactions such as prolonged swelling, bruising, vascular occlusion, unevenness, or infection at the injection site require prompt treatment with filler dissolution injections.
  • Desire to change shape or aesthetic results: Individuals who previously received filler injections may wish to change the shape of their lips, nose, cheeks, or other areas to better suit their current aesthetic needs.
Filler dissolution injections are a quick and safe solution, but they must be performed at a reputable facility and under the guidance of a qualified doctor to avoid risks and achieve optimal results.
When is filler dissolution injection necessary?
When is filler dissolution injection necessary?

Common Side Effects After Filler Dissolving Injections

Filler dissolving injections are a safe procedure if performed correctly, but sometimes the body may still have a mild physiological reaction. Understanding common side effects will help you feel more at ease and know how to care for your skin after the injection.

Swelling, redness, and mild bruising at the injection site

After filler dissolving injections, mild swelling, redness, or bruising at the injection site is a normal reaction of the body. This condition usually subsides after 1–3 days without leaving any long-term complications.
Swelling, redness, and mild bruising at the injection site
Swelling, redness, and mild bruising at the injection site

Itching, stinging, or burning sensation

Some people may experience itching, stinging, or burning at the injection site. This is a normal physiological reaction due to the body’s interaction with the enzyme hyaluronidase, which helps dissolve the filler.

Dry skin or mild peeling

After the filler dissolves, the skin may experience dryness or mild peeling, as this area needs time to recover and regenerate its natural protective layer. Proper moisturizing will help the skin recover faster.

Side effects related to skin pigmentation

In rare cases, the skin may experience hyperpigmentation or mild darkening after filler dissolution injections. Usually, these phenomena improve on their own after a few weeks without medical intervention.

Rare serious side effects of filler dissolution injections

Although rare, some serious reactions after filler dissolution injections can occur if proper injection procedures or skin care are not followed. Early recognition of abnormal signs will help in timely intervention and limit complications.

Infection or dermatitis

This is often caused by poor hygiene, non-sterile injection equipment, or improper post-injection skin care. If swelling, redness, increased pain, or pus appears at the injection site, contact your doctor immediately for prompt treatment.
Serious side effects are rare when fillers are dissolved.
Serious side effects are rare when fillers are dissolved.

Allergic Reaction to Filler Dissolving Enzyme

In rare cases, an allergic reaction to the enzyme hyaluronidase may occur, manifesting as swelling, redness, or intense itching. If this occurs, close monitoring and prompt medical intervention are necessary to ensure safety.

Skin Deformity or Indentation

Skin deformation or indentation can occur when filler injections are performed incorrectly or when an overdose of dissolving enzyme is used. In this situation, only an experienced doctor can safely correct and restore the skin’s shape.

Important Note Before Filler Dissolving Injections

Before undergoing filler dissolving injections, the most important thing is to choose a reputable aesthetic clinic with certified and experienced doctors to ensure optimal safety and effectiveness. Hbio Clinic is one of the reliable addresses, with a team of experienced specialists, modern equipment, and a completely sterile injection process, minimizing the risk of side effects.
Additionally, you should carefully check the type of filler, dosage, injection technique, and discuss any personal health issues or allergy history with your doctor. Being fully prepared before the injection will give you peace of mind, minimize risks, and ensure the best possible treatment results.
Important notes before filler dissolution injections.
Important notes before filler dissolution injections.

In general, most side effects of filler dissolution injections are mild and temporary, and can be managed if you follow your doctor’s instructions and take proper care of your skin. To ensure absolute safety, you should choose a reputable aesthetic clinic like Hbio Clinic, which has a team of experienced doctors, a standardized medical injection procedure, and modern technology. Thorough preparation before the injection and post-treatment monitoring will help you achieve the desired aesthetic results while protecting your skin health.


Dr. Thai Nguyen – Founder and Medical Director of HBIO Clinic. As an expert in aesthetic dermatology, she regularly shares in-depth knowledge and practical experience to provide valuable and insightful information for those seeking better skin health.